Endocrine Abstracts

Introduction: Mesenchymal bone marrow cells (BMCs) contain pluripotent progenitor cells, which differentiate into multiple lineages. In a previous study, we reported that adenovirus-mediated forced expression of steroidogenic factor-1/adrenal 4 binding protein (SF-1/Ad4BP), an essential nuclear receptor for steroidogenesis, could transform human BMCs into steroidogenic cells, suggesting a possibility of cell transplantation therapy in patients with steroid deficiency. In this ...

Androgen is an important factor for determining body composition in males. Abdominal obesity is inversely correlated with serum androgen levels in men. Androgen receptor (AR) null male mice revealed late-onset visceral obesity, accompanying energy balance abnormality. We previously reported a novel synthetic steroid, S42 as a promising candidate of a selective androgen receptor modulator (SARM). When orchiectomized Sprague-Dawley rats were administered with S42 for 3 weeks, th...

Japan has been regarded as a nongoitorous country due to the regular intake of iodine-rich food. However, nationwide information on current status of iodine intake is not available because there is no survey system for iodine nutrition in Japan.Objective: The objectives of this study is to characterize current iodine status in Japan.Methods: Since 2002 we have conducted studies on iodine nutrition in the Metropolitan area including...

Primary aldosteronism (PA) is the most major cause of secondary hypertension, with its prevalence ranging from 3 to 20% of the hypertensive patients. Although guideline for diagnosis of PA has been established by the Endocrine Society, details of its applicability remain to be elucidated. In this study, we investigated the applicability of each step of the guideline in hypertensive patients by the multi-center collaborative study of National Hospital Organization (NHO) in Japa...